380 10 Lec 5

380 10 Lec 5 - C Recognize healthy versus infected cells...

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Biology 380 Spring 2010 Immunology Henson Lec. 5: Innate Immunity IV & a Review of Immune System Cells and Organs 1. Interferons ( α and β ) produce a virus resistance state in infected cells and their neighbors. A. Work via the JAK-STAT pathway (which is used by many cytokines). B. Eliminate RNA and protein synthesis to help stop viral replication. C. Help increase expression of NK-specific receptor ligands and also directly activate NK cells. 2. NK cells. A. Very important in anti-viral responses. Defined as cytotoxic, large granular lymphocyte, mononuclear cells that lack CD3 (and therefore are not Tc cells) and express CD56 on surface. B. Have two types of receptors that can be either inhibitory or activating. - Immunoglobulin-like receptors - Lectin-like receptors (activating = NKG2D)
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Unformatted text preview: C. Recognize healthy versus infected cells.- Immunoglobulin-like inhibitory receptors interact with MHC class I.- Lectin-like NKG2D interacts with MIC proteins expressed by viral infected cells. D. Kill by either direct lysis (rare) or induction of apoptosis in target cell. - Release perforin and granulysin ⇒ membrane pore for entry of granzymes ⇒ apoptosis.- Can use the ADCC pathway. 3. A review of the cells discussed in lab last last week. A. Lymphocytes B. Non-lymphocytes C. Bone marrow and hematopoesis. D. APCs = Ag-presenting cells 4. A review of the organs of the immune system: Lymph nodes, Spleen, Thymus, and MALT Note: We are finishing Chapter 2 and going back to review material in Chapter 1. Quiz #1 will occur on Friday....
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