380 10 Lec 8 - multiple myeloma C Rodney Porter Gerald...

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Biology 380 Spring 2010 Immunology Henson Lec 8: Characteristics of Antigens (Ags) and Antibodies (Abs) 1) Deriving the important characteristics of Ags. 2) Discriminating between B and T cell epitopes (epitope = antigenic determinant) A. Binding of soluble whole antigen vs. binding to processed/presented peptides. B. Aspects of MHC “restriction” of T helper activation and T cytotoxic killing. a. Ag processing is essential for T cell activation. b. Classic experiments demonstrating MHC restriction. - MHC II restriction for T H cells. - MHC I restriction for T C cells 3) Probing the nature of antibodies. A. Immunoglobulins = antibodies. - Hapten-based studies prove that Abs are exquisitely specific. B. Antibody structure and sequence studies were facilitated through Henry Kunkel’s use of patients with
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Unformatted text preview: multiple myeloma. C. Rodney Porter, Gerald Edelman, and Alfred Nisonoff chemically dissect antibodies and discover Fab, Fc and light & heavy chains. 4) Antibody structure. A. Antibody arms are connected by a flexible hinge region B. Heavy and light chains contain variable and constant regions. C. The immunoglobulin fold domain. Note: Antibody structure and diversity generation is covered in Chap 4. Recall that you need to answer the questions (they will be posted later today) about the Fuch’s paper (currently available on Blackboard) prior to coming to class on Friday. Fuchs et al., 2007. Novel cell death program leads to neutrophil extracellular traps. J. Cell Biol. 176:231-241....
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