380 10 Lec 10

380 10 Lec 10 - Biology 380 Immunology Lec 10: Antibody...

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Biology 380 Spring 2010 Immunology Henson Lec 10: Antibody Structure, Function and Genetic Diversity 1) Ab light chain and heavy chain isotypes and immunoglobulin classes. A. Light chains: κ, λ B. Heavy chains: γ , μ , α , δ , ε = IgG, IgM, IgA, IgD, IgE 2) Effector functions of Abs. A. Agglutination and precipitaion. B. Opsinization and phagocytosis. C. Neutralization. D. Activation of complement E. Mediation of allergic reactions F. Ab-dependent cell-mediated cytotoxicity (ADCC) 3) Abs functioning as B cell receptors. 4) Puzzling aspects of Ab diversity. A. Human B cells can recognize several million different Ags. How is this possible given the limited number of human genes? - Germ line versus somatic variation. B. Comparing CDR regions of Abs from the same individual. C. Identical heavy and light chain CDR regions are associated with IgM and IgG molecules within the context of a single immune response. 5) Susumu Tonegawa’s critical experiment (he received the Nobel Prize in 1987).
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This note was uploaded on 03/09/2010 for the course BIO 380 taught by Professor Henson during the Spring '10 term at Dickinson.

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380 10 Lec 10 - Biology 380 Immunology Lec 10: Antibody...

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