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380 10 Lec 12

380 10 Lec 12 - Biology 380 Immunology Lec 12 Antibody...

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Biology 380 Spring 2010 Immunology Henson Lec 12: Antibody Genetic Diversity II 1) Genetic rearrangements and posttranscriptional processing in the generation of Ig light and heavy chains. A. Light chains are encoded by V, J, and C gene segments. B. Heavy chains are encoded by V, D, J, and C gene segments. 2) What is the mechanism of the variable region DNA rearrangements? A. Involves recognition of recombination signal sequences (RSS) that flank V, D and J segments. B. Recombination Activating Genes = RAG-1 and RAG-2. - Schatz, Oettinger and Baltimore’s elegant experiments on RAGs. (MA Oettinger, DG Schatz, C Gorka, and D Baltimore (1990). RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 248:1517 – 1523). C. The addition of nucleotides during the formation of the coding joint is mediated by terminal deoxynucleotidyl transferase (TdT) and contributes to junctional diversity. D. RAGs and TdT enzymes are the only lymphoid cell-specific enzymes needed to account for the DNA
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