380 10 Lec 12

380 10 Lec 12 - Figure 2-31 Sci ence 22 June 1990 Vol 248...

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Immunoelectrophoresis
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Figure 2-31
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Science 22 June 1990: Vol. 248. no. 4962, pp. 1517 – 1523 RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination MA Oettinger, DG Schatz, C Gorka, and D Baltimore Whitehead Institute for Biomedical Research, Cambridge, MA 02142. The vast repertoire of immunoglobulins and T cell receptors is generated, in part, by V(D)J recombination, a series of genomic rearrangements that occur specifically in developing lymphocytes. The recombination activating gene, RAG-1, which is a gene expressed exclusively in maturing lymphoid cells, was previously isolated. RAG-1 inefficiently induced V(D)J recombinase activity when transfected into fibroblasts, but cotransfection with an adjacent gene, RAG-2, has resulted in at least a 1000-fold increase in the frequency of recombination. The 2.1-kilobase RAG-2 complementary DNA encodes a putative protein of 527 amino acids whose sequence is unrelated to that of RAG-1. Like RAG-1, RAG-2 is conserved between species that
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380 10 Lec 12 - Figure 2-31 Sci ence 22 June 1990 Vol 248...

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