380 10 Lec 13

380 10 Lec 13 - Biology 380 Spring 2010 Immunology Henson...

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Unformatted text preview: Biology 380 Spring 2010 Immunology Henson Lec 13: Case Study #3 and the T Cell Receptor I. Case Study #3: Dennis and Daisy both have hyper-IgM immunodeficiency but the root causes are different. Read the cases and examine the accompanying figures in order to answer the following questions: 1) The B cells from Dennis express both IgM and IgD but apparently no other class of Ig. How is it possible to get these two types of Igs if his class switching process does not appear to function? 2) Given the functions of the various classes of Igs, why isn’t having high IgM levels (like Dennis and Daisy) enough to protect someone from severe bacterial infections? 3) Why did Dennis make Abs to the blood group A and O Ags but not to tetanus toxoid, typhoid O and H and streptolysin Ags? (Think about how T cells need to help B cells respond to certain Ags). 4) In Fig 3.5 it shows that activated T cells from Dennis (Patient 1) do not bind the protein CD40 (upper FACS graphs). What are the functions of CD40 and the associated CD40 ligand, what type of cells express them, and...
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