MCMP%20408%20Midterm%202008

MCMP%20408%20Midterm%202008 - NOTE: KEY ATTACHED AT END OF...

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Name: ____________________________ MCMP 408 MIDTERM EXAM February 28, 2008 100 Points Directions 1. There are 50 multiple choice questions. Select the ONE most correct answer and place all answers on the ScanTron sheet provided using a #2 pencil. 2. PLEASE KEEP SCANTRON SHEETS COVERED AT ALL TIMES 3. DO NOT LOOK AROUND DURING THE EXAM. ANY SUSPICIOUS BEHAVIOR WILL RESULT IN INDIVIDUALS BEING MOVED TO THE FRONT OF THE ROOM. 4. Results from the midterm exam will be posted on Blackboard WebCT by Tuesday, March 4. 5. At the end of the exam, turn in BOTH your question packet and the ScanTron Sheet. NOTE: KEY ATTACHED AT END OF EXAM
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1. The direction of flow of ions through an open ion channel depends upon all of the following EXCEPT: A. The concentration of ions on either side of the membrane B. The charge of the ions C. The membrane potential D. The concentration of ATP in the cell 2. Which of the following cations have an approximately 20,000 fold concentration gradient across the cell membrane? (i.e. the concentration is 20,000 time higher on one side of the membrane compared to the other side). A. Na + B. Ca 2+ C. K + D. None of the above 3. One hallmark of voltage-gated ion channels is: A. Regularly-spaced negative charges in the S6 helices B. Very inflexible inner helices C. Regularly-spaced positive charges in the S4 helices D. Highly conserved ATP-binding domains 4. For a K + -selective channel, which of the following is true? A. The selectivity filter is the narrowest part of the pore B. The aqueous vestibule is the narrowest part of the pore C. The inner helices are extremely inflexible D. The selectivity filter undergoes large conformational changes upon opening 5. In vascular smooth muscle, the DIRECT effect of Ca 2+ influx via L-type Ca 2+ channels is: A. Release of Ca 2+ from internal stores B. Activation of myosin light chain kinase C. Displacement of tropomyosin from the actin filament D. Activation of protein kinase C 6. In skeletal muscle: A. Extracellular Ca 2+ is not required for muscle contraction B. Ca 2+ channel blockers do not inhibit contraction C. L-type Ca 2+ channels act as a voltage-switch to open ryanodine receptors and release Ca 2+ from the sarcoplasmic reticulum D. All of the above 2
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7. The drug listed below exhibiting the highest degree of frequency-dependent Ca 2+ channels block is: A. Amlodipine (Norvasc) B. Nimodipine (Nimotop) C. Diltiazem (Cardizem) D. Isradapine (DynaCirc) 8. The drug with the greatest degree of vascular selectivity listed below is: A. Nifedipine (Procardia) B. Felodipine (Plendil) C. Verapamil (Calan) D. Diltiazem (Cardizem) 9. Dihydropyridines are selective for blocking Ca 2+ channels in vascular smooth muscle over Ca 2+ channels in cardiac muscle PRIMARILY because: A. They are more potent than other classes of Ca 2+ channel blockers B. They exhibit more frequency-dependent block that other Ca 2+ channel blockers C. The Ca 2+ channels in vascular smooth muscle and cardiac muscle are different gene products. D.
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MCMP%20408%20Midterm%202008 - NOTE: KEY ATTACHED AT END OF...

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