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MCMP%20408%20Midterm%202009%20key

MCMP%20408%20Midterm%202009%20key - Name_KEY MCMP 408...

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Name: _____ KEY __________________ MCMP 408 MIDTERM EXAM MARCH 5, 2009 100 POINTS Directions 1. There are 50 multiple choice questions. Select the ONE most correct answer and place all answers on the Scantron sheet provided using a #2 pencil. 2. PLEASE KEEP SCANTRON SHEETS COVERED AT ALL TIMES. 3. DO NOT LOOK AROUND DURING THE EXAM. ANY SUSPICIOUS BEHAVIOR WILL RESULT IN INDIVIDUALS BEING MOVED TO THE FRONT OF THE ROOM. 4. Results from the midterm exam will be posted on the class Blackboard by Tuesday, March 10. 5. At the end of the exam, turn in BOTH your question packet and the Scantron Sheet.
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1. In acetaminophen-induced liver toxicity: a. Glutathione metabolism by CYP450 is induced b. Toxic metabolites are generated by CYP2E1 c. Liver N-acetylcysteine is depleted d. All of the above 2. Rapid acetylators of hydralazine are prone to auto-immune-like disease: a. True b. False 3. Which of the following is a potent inducer of S-warfarin metabolism: 4. Succinlycholine apnea is associated with: 5. Teratogenesis is classified as a reproductive toxicity: 6. Which of the following would inhibit MPTP toxicity: a. Selegiline b. Grapefruit juice c. Ketoconazole d. R-Warfarin 7. Pharmacogenomic analysis can be used to:
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8. Phase 4 drug evaluation is best described as: a. Pre-marketing surveillance b. Post-marketing surveillance c. Preclinical efficacy evaluation d. Postclinical drug metabolism analysis 9. Thalidomide is: 10. Toxicogenomic analysis of a new drug candidate:
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