MCMP%20408%20quize%20-2007

MCMP%20408%20quize%20-2007 - Last Six Digits of Student...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Last Six Digits of Student ID#_____ KEY ______________ Answer the following questions in the space provided. 1. Answer the following questions about acetaminophen-induced liver toxicity (6 points). A) Explain why acetaminophen liver toxicity is not classified as an idiosyncratic drug reaction: Acetaminophen liver toxicity is a concentration related toxicity (overdose) whereas an idiosyncratic drug reaction results from an abnormal genetic predisposition. B) Predict the effect of concurrent high dose cimetidine therapy on acetaminophen liver toxicity. Provide an explanation of your answer. Cimetidine is a CYP 450 inhibitor (inhibits 2E1) which in turn would reduce the rate of acetaminophen metabolism, thus reducing the rate of toxic metabolite formation to decrease the level of liver toxicity. C) Predict the effect of concurrent heavy ethanol ingestion on acetaminophen-liver toxicity. Provide an explanation of your answer. Ingestion of large amounts of ethanol can lead to depletion of liver glutathione stores and induce CYP 2E1, thus increasing the rate of toxic metabolites formation and reducing its removal via glutathione conjugation. The result is a potentiation of acetaminophen-induced liver toxicity. 2.
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/11/2010 for the course MCMP 123 taught by Professor -- during the Spring '10 term at Purdue University-West Lafayette.

Page1 / 3

MCMP%20408%20quize%20-2007 - Last Six Digits of Student...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online