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quiz 2 2006 - 1 Would you predict the following drugs to...

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1. Would you predict the following drugs to cause reflex tachycardia? Explain why or why not. A. Hydralazine (Apresoline) Yes (1 pt), it is a vasodilater that will cause the baroreceptors to activate the sympathetic system to stimulate the heart (2 pts). B. Carvedilol (Coreg) No (1 pt), it blocks both alpha and beta receptors, thus even though it will cause vasodilation (alpha effect), the beta receptors are blocked preventing stimulation of the heart. 2. Below is shown the structures of two drugs. Drug A is an older carbonic anhydrase inhibitor. CH 3 H 2 NO 2 S SO 2 NH 2 NH H 2 NO 2 S COOH Cl Drug A Drug B CH 2 O A. How would drug B compare to drug A with regards to: Diuretic activity: More diuretic activity (2 pts) Carbonic Anhydrase activity: Less carbonic anhydrase activity (2 pts) B. What is the most likely pharmacological target for Drug B? Na/K/Cl co-transporter in the thick ascending limb of the loop of Henle (2 pts)
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