quiz 4 2008

quiz 4 2008 - 1. Nitric oxide is an important physiological...

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1. Nitric oxide is an important physiological modulator of vascular tone. A. Explain why damage to the endothelium in blood vessels can result in vasoconstriction. (2 pts) The endothelium is the site of eNOS and NO production. (1) Therefore, damaged endothelium can reduce local production of NO, and in an increase in vascular tone. (1) B. Explain why organic nitrates such as glyceryl trinitrate are effective in blood vessels with damaged endothelium. (2 pts) GTN is a NO generating drug, so eNOS is bypassed. (1) The target for NO, guanylyl cyclase, resides in the vascular smooth muscle, so the response to NO is intact. (2) C. Give an example of a drug that potentiates the activity of endogenous nitric oxide. (2 pts) Sildenafil (Viagra), Tadalafil (Cialis), or Vardenafil (Levitra) potentiate the effect of NO by inhibiting the breakdown of cGMP. 2. Mr. Payne frequently awakens at night with moderate to severe angina pectoris. He currently takes metoprolol (Lopressor) to help control his hypertension. A. How would you classify the type of angina that Mr. Payne is experiencing? (1 pt) Variant, Vasospastic, or Prinzmetal’s Angina B. Give a drug that should NOT be used to treat his angina if he continues to take metoprolol (1 pts),
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quiz 4 2008 - 1. Nitric oxide is an important physiological...

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