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quiz 6 2007 - 1 Fill in the blanks with the correct drug(s...

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1. Fill in the blanks with the correct drug(s) from the list of compounds given below. Note that each blank may have more than one answer and each compound may be used more than once (6 points). -This drug is a direct thrombin inhibitor __ Argatroban ____________ -It is important to frequently perform coagulation testing during therapy with this drug _ Heparin/warfarin ________ -An antagonist to heparin ___ Protamine sulfate __________________ -Inhibits platelet aggregation by blocking the GPIIb/IIa receptor ___ Eptifibatide ________________________ -Crosses the placenta to produce teratogenic effects in the fetus ___ Warfarin __________________________________ Aspirin Vitamin K Warfarin Eptifibatide Protamine sulfate Heparin Argatroban 2. Answer each of the following by considering the underlying mechanism of action of each compound. A. Explain why heparin is classified as an indirect thrombin inhibitor. (2 points) Heparin’s inhibition is indirect since it binds with antithrombin III to stimulate antithrombin mediated inhibition of thrombin. B . Explain why lepirudin is classified as a direct thrombin inhibitor. (2 points)
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