quiz%202 - 1 2 Below is a diagram of the kidney tubule...

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1. 2. Below is a diagram of the kidney tubule. Please provide the name of one drug that acts at the indicated sites of action. (2 pts each) Site 1__________________________________
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Site 1 could be any loop: furosemide, torsemide, bumetanide, or ethacrynic acid 3. A. Explain how acetazolamide (Diamox) causes diuresis (4 pts) Inhibition of carbonic anhydrase (2 pts) disrupts the movement of Na+ into blood (reduced Na+ reabsorption or disrupts Na+/H+ transporter/exchanger)(1 pt). Increased Na+ in urine = increased diuresis (1 pt) B. Why does acetazolamide (Diamox) cause increased potassium excretion in the urine? (2 pts) Increased delivery of Na+ to the collecting tubule (1 pt) promotes exchange of Na+ and K+ (1 Na+ into blood = 1 K+ into urine/excretion) (1 pt) 4. Of the following diuretics which one would most likely lead to the most pronounced diuretic effect? Circle the most efficacious agent (3 pts) Torsemide (Demadex) Acetazolamide (Diamox) Triamterene (Dyrenium) Explain your answer. (3 pts)
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Torsemide is a loop diuretic (1 pt). Loop diuretics block the Na/Cl/K transporter in the loop to
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This note was uploaded on 03/11/2010 for the course MCMP 123 taught by Professor -- during the Spring '10 term at Purdue.

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quiz%202 - 1 2 Below is a diagram of the kidney tubule...

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