Quiz%204%20MCMP%20408%202009

Quiz%204%20MCMP%20408%202009 - Quiz 4 MCMP 408 1....

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Quiz 4 MCMP 408 1. Atherosclerosis often leads to damage to the endothelial layer of blood vessels. A. Explain why damage to the endothelial layer can lead to vasoconstriction. (2 pts) This is the site of NO production by eNOS (1 pt), and NO is an important vasodilator (1 pt). B. What type of angina pectoris is caused by atherosclerosis? (1 pts) Classic or stable angina C. What is an ENZYME that can generate cGMP accumulation in a manner that does not require an intact endothelium? (2 pts) Membrane-bound (or particulate) guanylyl cyclase D. What is a drug that activates the enzyme that you gave in answer to question C? (1 pts) Nesiritide (Natrecor) 2. In regard to the treatment of angina pectoris, explain the rationale for the following combination treatments: A. Calcium channel blocker and beta-adrenergic receptor antagonist ( β -blocker) (1 pt) CCBs can dilate coronary arteries and increase oxygen supply to the myocardium. Beta blockers can decrease oxygen demand by decreasing HR and force of contraction. B.
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This note was uploaded on 03/11/2010 for the course MCMP 123 taught by Professor -- during the Spring '10 term at Purdue University-West Lafayette.

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Quiz%204%20MCMP%20408%202009 - Quiz 4 MCMP 408 1....

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