quiz%202008 - 1. Fill in the blanks regarding the...

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a. ________________ angiotensinogen ___________________________ Angiotensin I Angiotensin II Angiotensin III 2. Describe the molecular mechanism associated with cleavage of angiotensin I to angiotensin II by angiotensin converting enzyme (3 pts), and how lisinopril (Prinivil, Zestril) leads to inhibition of this process (3 pts). Angiotensin I binds to the active site with the carboxyl end of the peptide binding to a positively charged arginine (1 pt). A zinc molecule polarizes (makes it susceptible to nucleophilic attack) the carbonyl (1 pt) so that a glutamate will attack the carbonyl carbon on Angiotensin I (between the Phe and His) to cleave the bond (1 pt). Lisinopril binds in the active site (1 pt) and interacts with the Arg and Zn (1 pt) to competitively inhibit the binding of Angiotensin I ( 1 pt). b. ____
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This note was uploaded on 03/11/2010 for the course MCMP 123 taught by Professor -- during the Spring '10 term at Purdue University.

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quiz%202008 - 1. Fill in the blanks regarding the...

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