Lecture Notes week 7-8

Lecture Notes week - Late Intestinal phase Exocrine secretions Pancreas duct cells HCO3 rich juice Acinar cells zymogens Liver and gall bladder

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11/9/09 Late Intestinal phase Exocrine secretions Pancreas: duct cells: HCO3- rich juice Acinar cells: zymogens Liver and gall bladder: bile: bile salts Bile pigments Cholesterol P lipids Ions and water Digestion and absorption Carbohydrates, proteins, lipids, vitamins, Ca2+, Fe2+, etc. Exocrine secretions: secretin that activates the duct and ancinar cells; HCO3- neutralizes acidic conditions to pH 8. Figure 21-8 1. Carbon dioxide goes into the cell, also CO2 from the metabolic processes within the cell 1. Carbon dioxide converted to bicarbonate ion and H+ 2. HCO3- goes into the lumen via HCO3-/Cl- antiport 3. Cl- goes back into the lumen via CFTR channel
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4. CFTR Channels 1. Cystic fibrosis transmembrane regulator 2. Is chloride selective 3. Gated inside the cell by cyclic AMP 4. If there is an increase in cyclic AMP then the channel opens and chlorine leaves 5. These types of channels are found in the pancreatic ducts, small intestine, colon, sweat glands, trachea and bronchus 6. If the channel doesn’t work, sweat becomes very salty
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This note was uploaded on 03/12/2010 for the course BIPN BIPN 102 taught by Professor Fortes during the Fall '09 term at UCSD.

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Lecture Notes week - Late Intestinal phase Exocrine secretions Pancreas duct cells HCO3 rich juice Acinar cells zymogens Liver and gall bladder

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