Cell bio test 4 - Principles of Cell Biology Exam 4 Directions There are 75 questions in this exam with only one correct answer for each question

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Principles of Cell Biology Exam 4 May 16, 2006 Directions : There are 75 questions in this exam with only one correct answer for each question. All answers are to be placed on the grid sheet . Don’t forget to enter your name and last 4 numbers of your social security number in the appropriate places on your answer sheet . 1. What is the function of thymosin β 4? a. It caps F-actin at the - end b. It sequesters ATP-bound G-actin and, as such, increases the G-actin cytoplasmic reserves c. It facilitates ATP/ADP exchange associated with G-actin d. It caps microtubules but only at the + end e. It is an F-actin severing protein 2. Which of the following defective proteins can contribute to the conversion of a normal to a cancer cell? a. Growth factors b. Growth factor receptors c. Intracellular transducers d. DNA repair proteins e. All of the above proteins can contribute to the conversion of a normal to a cancer cell if they are defective. 3. Which of the following is regarded as the “guardian of the genome”? a. P21 cip b. ATM/R c. Chk1 d. P 53 e. Cyclin-D/CDK4/6 4. The multi-hit model of cancer states that oncogenes can a. Be synergistic in their functions b. Be additive in their functions c. Cancel each other out d. Can be transferred from mouse to human cells e. Originate due to a number of different factors that include radiation, chemical mutagens, etc. 5. Asymmetric division is best represented by : a. A hematopoeitic stem cell that produces a monocyte b. A somite that becomes a myoblast upon MyoD induction c. A preadipocyte cell that is induced to differentiate into a fat cell by C/EBP expression d. A gamete that is fully differentiated into a neuron e. None of the above
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6. An increase in Cyclin B levels occurs just prior to what cell cycle phase? a. G 1 b. S c. G 2 d. M e. G 0 7. The erbB oncogene is most related to which receptor? a. Insulin b. PDGF c. EGF d. NGF e. DMBF 8. Of the following cancers, which has the steepest slope of incidence over the lifetime of an individual? a. Skin b. Rectum c. Pancreas d. Esophagus e. Prostate 9. Which of the following cell types is anucleate (does not contain a nucleus)? a. Regenerative (basal) cells in human skin b. Human fibroblasts c. Lens epithelial cells d. Lens fiber cells e. Rods and cones of the retina 10. Many new drugs are currently being used or developed as anti-cancer drugs because they attack tumor-driven angiogenesis. What is angiogenesis? a. Mutation of p53 b. Formation of new blood vessels c. Mutation of ras d. Over-expression of oncoprotein receptors on tumor cells e. The ability of cancer cells to “skip” G 2 so that they can divide faster. 11. An experiment described in class using a fish pigment cell demonstrated that if a piece of the cell was cut off that contained microtubules but did not contain a MTOC then : a. Microfilaments would replace the microtubules b. The microtubules would immediately depolymerize into single tubulin dimers c. Microtubules would reorganize into a radial array even without a new MTOC
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This note was uploaded on 03/12/2010 for the course BIOL 311 taught by Professor Vanbuskirk during the Spring '08 term at Binghamton University.

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Cell bio test 4 - Principles of Cell Biology Exam 4 Directions There are 75 questions in this exam with only one correct answer for each question

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