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7 - TA Christine Feng [email protected] Section Mon 4-5...

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TA: Christine Feng [email protected] Section: Mon 4-5 Center 205 OH: Wed 11-12 Geisel S&E This Week In Lecture: Lipid Bilayer Phospholipids Membrane Permeability Bacteriorhodopsin Porins K+ Channel Chapter 12 Lipid Bilayer Fundamental structure of cell membranes – of same rank of importance as DNA double helix & α helix/ β sheets of proteins Very thin film ~40 Å with hydrophobic core separating 2 aqueous compartments Separates exterior from interior Montal’s proposed origin of life Consists mainly of lipids & proteins, some cholesterol Fragmentation form vesicles (i.e. micelles) Acts as a permeability barrier for ions, nutrients, etc. Similar to soap molecules: amphipathic (carboxylate polar head & long hydrophobic tail) o Tail can be saturated or unsaturated (introduce kink, i.e. oleate) o Look for lowest energy conformation o In excess of water: form spherical micelles Phospholipids
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