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Unformatted text preview: TA: Christine Feng [email protected] Section: Mon 4-5 Center 205 OH: Wed 11-12 Geisel S&E This Week In Lecture: • Signal Transduction • G-Protein Coupled Receptors • Cholera Toxin (CT) • Receptor Tyrosine Kinases • Adaptor Domains • Human Growth Hormone (GH) • Protein Stability Review Signal Transduction • Primary messenger (i.e. hormone) binds to receptor – induces change in protein • Signal transmitted across membrane secondary messenger inside cell that activates proteins that alter the biochemical circuitry inside the cell • Net result is amplification, fidelity, & diversity • Mechanisms to terminate signal transduction pathway G-Protein Coupled Receptors (GPCR) • Many functions – see slides from lecture • Trimeric protein consisting of α , β , γ units ( α & β lipid linked) o α subunit is similar to Ras protein • Bound to receptor with 7 transmembrane α helices on cytosolic side • Common secondary messengers: cAMP, calcium, IP3, DAG • β-adrenergic receptor – adrenaline/epinephrine • Adenylate cyclase – target protein of GPCR, converts ATP to...
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This note was uploaded on 03/12/2010 for the course BIBC BIBC 100 taught by Professor Buehler during the Winter '09 term at UCSD.
- Winter '09