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9 - TA Christine Feng [email protected] Section Mon 4-5...

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TA: Christine Feng [email protected] Section: Mon 4-5 Center 205 OH: Wed 11-12 Geisel S&E This Week In Lecture: Signal Transduction G-Protein Coupled Receptors Cholera Toxin (CT) Receptor Tyrosine Kinases Adaptor Domains Human Growth Hormone (GH) Protein Stability Review Signal Transduction Primary messenger (i.e. hormone) binds to receptor – induces change in protein Signal transmitted across membrane secondary messenger inside cell that activates proteins that alter the biochemical circuitry inside the cell Net result is amplification, fidelity, & diversity Mechanisms to terminate signal transduction pathway G-Protein Coupled Receptors (GPCR) Many functions – see slides from lecture Trimeric protein consisting of α , β , γ units ( α & β lipid linked) o α subunit is similar to Ras protein Bound to receptor with 7 transmembrane α helices on cytosolic side Common secondary messengers: cAMP, calcium, IP3, DAG β -adrenergic receptor – adrenaline/epinephrine
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