L38 2009 Migration

L38 2009 Migration - Navigation & Orientation Learning &...

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Orientation Lecture 38 25 November 2009 AMPA receptor Aplysia associative learning CA1 CA3 classical conditioning conditioned stimulus conditioned response critical period dishabituation food aversion learning glutamate habituation hippocampus imprinting insight learning latent learning long term potentiation LTP Morris water maze NMDA receptor non-associative learning operant conditioning Pavlovian conditioning sensitization serotonin spatial learning tetanus unconditioned stimulus unconditioned response Synaptic plasticity in the hippocampus is a neural correlate of learning (part of forebrain diencephalon) Rodent axons Slow stimulation: 2-3 per min, constant EPSP After stimulus burst (tetanus), long lasting increase in EPSP Long term potentiation (LTP) CA1 neuron CA3 neuron Long term potentiation (LTP) at synapse 1 mediated by NMDA type glutamate receptor
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More channels are made and inserted into the post-synaptic membrane resulting in stronger synaptic transmission CA1 neuron CA3 neuron Associative LTP: When both CA3 inputs fire together (below right), both synapses onto CA1 become stronger CA3 CA3 CA1 to CR UCS CS LTP in this hippocampal circuit shares properties with behavioral associative learning
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This note was uploaded on 03/13/2010 for the course BIOG 1101 taught by Professor N/a during the Fall '10 term at Cornell.

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L38 2009 Migration - Navigation & Orientation Learning &...

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