50. 1102 Translation 10 - translation Robert Holley...

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Unformatted text preview: translation Robert Holley Professor of Biochemistry at Cornell when he sequenced tRNA. Nobel Prize in 1968. tRNA The genetic code (by convention read as RNA) Why is the genetic code almost universal? The protein-coding segment is often called the open reading frame (ORF) It is critical to start the ORF at exactly the right nucleotide Mutations template strand sickle-cell disease Mutations What happens if this G mutates to an A? Mutations What happens if this G mutates to an A? mRNA would read GGU i.e. glycine this is a silent mutation Mutations What happens if this T mutates to an A? Mutations What happens if this T mutates to an A? the codon reads UAG i.e. Stop nonesense mutation Mutations Where would the addition of an A have the most profound effect? Mutations Where would the addition of an A have the most profound effect? A frameshift mutation near the start of a gene has the most profound effect....
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50. 1102 Translation 10 - translation Robert Holley...

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