Lecture_23_2perpage

Lecture_23_2perpage - Introductory Developmental Genetics...

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1 Introductory Developmental Genetics “It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life” -Lewis Wolpert Topics Today I. How do genes control development? II. Example: Fly segmentation
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2 • Fertilization • Blastula (“ball of cells”) formation • Gastrulation – Folding in of blastula cells • Formation of germ-layers • Cellular differentiation • How do genes control this process? Major Events in Animal Development Worm Development (Fig C.7)
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3 Worm Cell Lineage (Fig C.7) Gene Expression in a Cell Gene Regulation Especially Regulation of Transcription History? Location? Neighbors? (External environment)
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I. Genes in Development A. Progressive Changes in Gene Expression (History) B. Development Utilizes Asymmetries (Location) C. Cells can communicate with each other (Neighbors) I.A. Progressive Changes in Gene Expression (History) • Mostly regulation of transcription – How do we know? In situ
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Lecture_23_2perpage - Introductory Developmental Genetics...

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