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Lecture_23_2perpage - Introductory Developmental Genetics...

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1 Introductory Developmental Genetics “It is not birth, marriage, or death, but gastrulation, which is truly the most important time in your life” -Lewis Wolpert Topics Today I. How do genes control development? II. Example: Fly segmentation
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2 • Fertilization Blastula (“ball of cells”) formation Gastrulation – Folding in of blastula cells Formation of germ-layers Cellular differentiation How do genes control this process? Major Events in Animal Development Worm Development (Fig C.7)
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3 Worm Cell Lineage (Fig C.7) Gene Expression in a Cell Gene Regulation Especially Regulation of Transcription History? Location? Neighbors? (External environment)
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4 I. Genes in Development A. Progressive Changes in Gene Expression (History) B. Development Utilizes Asymmetries (Location) C. Cells can communicate with each other (Neighbors) I.A. Progressive Changes in Gene Expression (History) Mostly regulation of transcription – How do we know?
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