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Lecture_24.supp2perpage

Lecture_24.supp2perpage - Types of molecular evolution...

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1 Types of molecular evolution Neutral – Mutation has no effect on fitness of the organism Positive selection – Mutation benefits fitness of organism and thus its frequency increases in the population Purifying selection – Mutation harms fitness and thus the allele is removed from population Synonymous vs Non-synonymous Mutation Synonymous (Doesn’t change amino acid) – Sometimes called Ks – Sometimes called d s Non-Synonymous (Changes Amino Acid) – Sometimes called Ka – Sometimes called d n
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2 Neutralist/Selectionist Debate Measuring Selection on Genes Gene Duplication Kimura – Neutral Theory of Evolution Hypothesized that most molecular change is the result of neutral changes Evidence: Molecular clock – (selection should be episodic)
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3 Neutralist – Selectionist Debate Debate about molecular level (not about phenotypes) • Selectionists – Molecular change driven by selection (adaptation) • Neutralists
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