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hw1 - PB HLTH C240D/STAT C245D/STAT 246 Spring 2009...

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Unformatted text preview: PB HLTH C240D/STAT C245D/STAT 246 Spring 2009 Assignment #1 Due: Tuesday, February 3rd, in class There are three main parts to this assignment. The first part concerns basic Mendelian genetic analysis; the second involves exploring biological WWW re- sources at the National Center for Biotechnology Information (NCBI); the third consists of installing R and Bioconductor software on your own computer. Part I. Mendelian Genetic Analysis Question 1. Mendel. Read Mendel’s (1866) paper ( www.mendelweb.org ). Question 2. Albinism. (Griffiths et al., 1996, Ex. 10, p. 48) Suppose that a husband and wife are both heterozygous for a recessive gene for albinism. If they have dizygotic (two-egg) twins, what is the probability that both twins have the same phenotype for pigmentation? Question 3. Tay-Sachs disease. (Griffiths et al., 1996, Ex. 16, p. 49) Tay-Sachs disease, or infantile amaurotic idiocy, is a rare human disease in which toxic substances accumulate in nerve cells. The recessive allele responsible for the disease is inherited in a simple Mendelian manner. A woman is planning to marry her first cousin, but the couple discovers that their shared grandfather’s sister died in infancy of Tay-Sachs disease. You may assume that the grand- father’s sister is the only affected individual in the family and that individuals marrying into the family do not carry the rare disease allele. a) Draw the relevant parts of the pedigree and infer genotypes....
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hw1 - PB HLTH C240D/STAT C245D/STAT 246 Spring 2009...

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