hw2 - PB HLTH C240D/STAT C245D/STAT 246 Spring 2009...

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Unformatted text preview: PB HLTH C240D/STAT C245D/STAT 246 Spring 2009 Assignment #2 Due: Tuesday, February 17th, in class This assignment concerns the statistical analysis of meiosis. Question 1. Map functions. Consider two loci A and B . Let X denote the random variable for the number of chiasmata between A and B on the four-strand chromatid bundle and let π n = Pr( X = n ), n = 0 , 1 , ··· , denote the chiasma count distribution. Consider the following three models for chro- matid strand involvement, where { 1 , 2 } and { 3 , 4 } denote the two pairs of sister chromatids. a) No-chromatid-interference (NCI). Each of the four pairs of non-sister chro- matids is equally likely to be involved in a chiasma, independently of strand involvement in other chiasmata. b) Complete-negative-chromatid-interference (-CI). The same randomly cho- sen pair of non-sister chromatids is involved in all chiasmata. c) Complete-positive-chromatid-interference (+CI). The pairs of non-sister chromatids involved in different chiasmata strictly alternate between the first randomly chosen pair and the other pair. For instance, if the first chi- asma involves pair { 1 , 3 } , then subsequent chiasmata alternately involve pairs { 2 , 4 } and { 1 , 3 } ....
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This note was uploaded on 03/14/2010 for the course C 240D, C24 taught by Professor S.dudoit during the Spring '09 term at Berkeley.

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hw2 - PB HLTH C240D/STAT C245D/STAT 246 Spring 2009...

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