NPB 100 Lecture 2

NPB 100 Lecture 2 - Lecture 2 -Topic of lecture: Neuronal...

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Lecture 2 -Topic of lecture: Neuronal membrane and ionic concentration gradients -Resting potential -Selective ionic permeability -Membrane currents -Ohm’s Law -Spikes -Voltage clamps -neurons are limited by cell membrane -biological membrane 3 components -phospholipids -proteins -actively inserted in membranes -carbohydrates -attached to proteins mostly -sometimes to lipids as well -membrane is thin -ions on opp sides -close enough together to feel attraction -thickness of membrane not variable -in squids -potassium higher in cells -sodium higher outside cells -chlorides higher outside -calcium higher outside (10000-fold difference) -metabolic pumps (protein) -maintain concentration gradients -transports Na out, K in
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-using ATP -membrane potential -patch clamp -differential amplifier -compares electric potential at 2 places -inside of cell vs outside -useful because output is -difference b/w the two electrodes -or membrane potential -50mV to -100mV -outside represents ground potential (zero potential) -graph: modification of [K] outside
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This note was uploaded on 03/15/2010 for the course NPB NPB taught by Professor Bales during the Winter '09 term at UC Davis.

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NPB 100 Lecture 2 - Lecture 2 -Topic of lecture: Neuronal...

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