NPB 100 Lecture 5

NPB 100 Lecture 5 - Lecture 5 -Postsynaptic potential (PSP)...

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Lecture 5 -Postsynaptic potential (PSP) -Calcium ion and graded release -Neurotransmitters -Receptors (pharmacology and molecular structure) -squid’s giant synapse (part of anatomy of escape circuit) -very large (look at picture in notes) -synaptic delay -depending on temperature of animal -greater than .4ms -when AP fails, in the postsynaptic membrane -see a depolarization that falls down (called postsynaptic potential) -gets overridden normally by action potential -factors affecting the size of the PSP -fatigue -ratio of Ca/Mg -voltage-gated Ca channels blocked by Mg -when increasing [Mg] or decreasing [Ca], see smaller PSP -affecting how much NT’s are going to be released -graded release of NT -transmitter released proportional to membrane potential of presynaptic cell -look at graph in notes
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-if you depolarize the presynaptic, you will see a rise in postsynaptic potential -if you hyperpolarize the presynaptic, it might sag down a bit in the postsynaptic -continuous relationship between presynaptic potential and postsynaptic potential caused by the change of calcium influx that is caused but the change in the presynaptic potential -presynaptic action potential depolarizes the terminal, allowing voltage-gate Ca channels to open, get release of NT, get postsynaptic potential maybe
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This note was uploaded on 03/15/2010 for the course NPB NPB taught by Professor Bales during the Winter '09 term at UC Davis.

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NPB 100 Lecture 5 - Lecture 5 -Postsynaptic potential (PSP)...

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