NPB 100 Lecture 11

NPB 100 Lecture 11 - -Synaptic plasticity: changes in the...

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-Synaptic plasticity: changes in the strength, property of synapses -Facilitation -Synaptic depression -Spike-timing dependent plasticity -Multiple synapses -Synaptic substrate of behavioral change -Aplesia gill withdrawal reflex -Changes in concentration of 2 nd messenger and changes in gene expression -Synaptic strength: if we have a synapse on a cell and we record the PSP, see how big PSP when synapse is active or can take integral (area under the PSP), which is equivalent to the total charge coming in. Can also measure synaptic current as a change -Synaptic depression: when a train of impulses is put in (the pulses are not close enough to summate), the strength of the synapse gets lower with each impulse. It is reversible. Frequency dependent and number of stimuli dependent change in strength. Not a result in changes in postsynaptic cell. During this train of stimuli, a reduction occurs in the quantal content. Number of quanta available for release is being reduced. Synaptic substrate for habituation. Habituation is reduction in behavioral response to repeated uninteresting stimuli. -Homosynaptic Facilitation: use-dependent increase.Can start of as relatively weak synapses and as you continue to stimulate them regularly, the synapse strength grows (is not due to
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NPB 100 Lecture 11 - -Synaptic plasticity: changes in the...

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