NPB 100 Lecture 12

NPB 100 Lecture 12 - -Long-term potentiation: Hippocampus...

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-Long-term potentiation: Hippocampus (declarative memory) -Site specific and associativity -Glutamate channels and glutamate receptors -AMPA receptors, NMDA receptors -Mechanism of long-term potentiation -Long-term depression -Hippocampus is a region of the anterior par tof the brain. Required for consolidation of declarative memory. -Information come in from the efferent pathway, from the neocortex, and go into the group of cells that send axons over to CA3 pyramidal cells. -Researches if measure the strength of synaptic response in the hippocampus, see increase in synaptic strength that looks like posttetanic potentiationg but lasts longer, for weeks. -Slide 3: stimulating 2 groups of axons and compare the EPSPs. One is quite stable while the other shows post-tetanic potentiation. This is an example of site specificity. Only one synapse shows the increase in EPSP. -Slide 4: what happens if you stimulate both at the same time, see increase in strength of both synapses. Associative. Need both associative and site-specific for declarative memory. -CA3 have dendritic spines. 2 types of receptors in the postsynaptic membrane. AMPA receptors
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NPB 100 Lecture 12 - -Long-term potentiation: Hippocampus...

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