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renal_lab_overview - Renal Lab Overview Expected outcomes...

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Renal Lab Overview Expected outcomes and mechanisms Subjects: 1) Control. Should see no changes, assuming well hydrated. 2) Isotonic. Increased volume load, no change in molality. 3) Hypotonic. Increased volume load, decrease molality. 4) Alkalosis. No appreciable change in volume, increased pH. Note: Keep in mind that each subject also serves as their own “internal” control! That is, you can compare changes over the course of the experiment to their initial (T=0) readings. Expected Outcomes: (expressed relative to internal control) Subject Specific Gravity pH Urine Flow rate GFR Creatinine clearance Na+ clearance Control No change No change No change No change No change No change Isotonic No change No change Increase Increase Increase May Increase Hypotonic Decrease No change Increase Increase Increase Decrease Alkalosis No change Increase! No change No change No change No change Mechanisms : Control subject: Assuming the subject was well hydrated prior to coming to lab, we shouldn’t have seen any changes in any variables over time for the control subject.
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