BCH4024 - Allen Lecture 21

BCH4024 - Allen Lecture 21 - Glycogen Metabolism...

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Glycogen Metabolism glycogen non-reducing termini Glycogenin α - 1,6 linkage
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α -1,4-glycosidic bond α -1,6-glycosidic bond p 249 Lehn
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Glyconeogenesis Glycogenolysis P i UDP-glucose Glucose -1- P Glucose Glucose –6- P Fructose –6- P Gluconeogenesis Glycolysis Glycogen synthase Glycogen phosphorylase α 1,6- Debranching enzyme UDP UTP 2 P i PP i Glycogen glycogen primer ATP ADP
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- Acting at non-reducing end - α 1,4-glycosidic bond is cleaved by phosphorolysis with retention of energy potential in phosphate ester of glucose-1- phosphate - stops four glucose residues from 1,6 branch point - contrast with enzymes of starch glycogen hydrolysis in gut which lead to sugar not sugar phosphates as products. - activated by phosphorylation, regulated by glucagon (see below) ( inorganic phosphate ) Glycogen Phosphorylase p 563 Lehn
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p 563 Lehn Degradation- Glycogenolysis Glucose-1-Ps Debranching enzyme Two activities Transferase Glycosidase hydrolysis
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Debranching Enzyme - transferase acts to transfer non-reducing trisaccharide from tetrasaccharide attached by 1,6 linkage to end of an adjoing chain to elongate this α 1,4 linked chain - glucosidase cleaves off the α 1,6 linked glucose as free glucose Phosphoglucomutase glucose-1-phosphate glucose-6-phosphate - reversible reaction - permits entry of glucose - 1 - P into glycolysis via glucose - 6 - P - permits entry of glucose - 6 - P into glycogen synthesis via
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This note was uploaded on 03/15/2010 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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BCH4024 - Allen Lecture 21 - Glycogen Metabolism...

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