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BCH4024 - Allen Lecture 22 - 23

BCH4024 - Allen Lecture 22 - 23 - Gluconeogenesis Synthesis...

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Gluconeogenesis Synthesis of glucose from small molecular precursors Pyruvate Lactate TCA cycle intermediates Some amino acid skeletons 2 Pyruvate + 4 ATP + 2 GTP + 2 NADH Glucose + 4 ADP + 2 GDP + 2 NAD + + 6 P i
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glucose Hexokinase glucose -6- phosphate Phosphoglucose Isomerase fructose -6- phosphate Phosphofructokinase - I fructose –1,6- bisphosphate Aldolase Triose phosphate isomerase dihydroxyacetone phosphate glyceraldehyde -3-phosphate Glyceraldehyde -3- phosphate Dehydrogenase 1,3- bisphosphoglycerate Phosphoglycerate Kinase 3 -phosphoglycerate Phosphoglyceromutase 2- phosphoglycerate Enolase phosphoenolpyruvate Pyruvate kinase pyruvate ATP ADP ATP ADP ADP ATP NAD + + P i NADH H 2 O ADP ATP malate oxaloacetate malate oxaloacetate mitochondrion NAD + NADH NAD + NADH GTP GDP + CO 2 ADP ATP + CO 2 Pyruvate carboxylase PEP carboxy kinase Fructose-1,6- bisphosphatase Glucose 6- phosphatase Gluconeogenesis + P I lactate see also p 544 Lehn
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p 544 Lehn
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