BCH4024 - Allen Lecture 30 - 33

BCH4024 - Allen Lecture 30 - 33 - BCH 4024 (2010)...

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BCH 4024 (2010) Recommended Readings From Lehninger Principles of Biochemistry for Allen’s Lectures In Metabolism Date Lecture 5 th Edition 2/5 Introduction to 485-488, 495-501 Intermediary Metabolism 2/8 Glycolysis I 527-551 2/9 Glycolysis II 583-589 2/10 Glycogen Metabolism 594-609 2/12 Gluconeogenesis I 551-558 2/15 Gluconeogenesis II 582-590 2/16 Tricarboxylic Acid Cycle I 615-638 2/17 Tricarboxylic Acid Cycle II 615-638 2/19 Tricarboxylic Acid Cycle III 615-638 2/22 Electron Transport/Oxidative 707-722,512-521 Phosphorylation I 2/23 Electron Transport/Oxidative 723-736 Phosphorylation II 2/24 Pentose Shunt 558-563 2/26 Lipid Structure and Function 343-357 3/1 Lipid Function 343-457 3/2 Fatty Acid Oxidation 647-665 3/3 Fatty Acid Biosynthesis 805-815,665-668 and Ketogenesis 3/5 Phospholipid Biosynthesis 820-827 3/15 Sterol Metabolism 831-845 3/16 Lipoproteins 831-845
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C 18:1 Δ 9 , oleic acid C 20:4 Δ 5,8,11,14 , arachidonic acid 10 9 5 11 8 14 1. Lipid Classes a. Simple fatty acids - saturated (e.g. C 16 and C 18 ) - unsaturated (e.g. C 18:1 and C 20:4 ) ( C 18:1 Δ 9 or C 20:4 Δ 5,8,11,14 ) p 344-345 Lehn
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b. Mono, di- and triglycerides e. g. triglyceride (triacylglyceride) component parts glycerol fatty acids c. Glycerolphospholipids (phosphoglycerides) e.g. lecithin (phosphatidyl choline) component parts glycerol fatty acids phosphate choline CH 3 CH 3 CH 3 + p 350 Lehn X
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d. Sphingolipids e.g. Sphingomyelin component parts sphingosine fatty acids phosphate choline p 354 Lehn
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e. Steroids e.g. Cholesterol p 355 Lehn
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f. Prostaglandins e.g. Prostaglandin E 2 (PGE 2 ) p 358 Lehn
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g. Lipid Vitamins p 360-362 Lehn
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Function of Lipids 1. Structural components of membranes 2. Storage forms of energy 3. Transporters of metabolic fuel 4. Emulsifying agents 5. Vitamins and Hormones 6. Hybrid molecules with specific functions 7. 2 nd messenger system: e.g. phosphatidyl inositol
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Membrane Structure p 374 Lehn A bilayer-lipid composition with integral and peripheral proteins contributes to the membrane structure. The Fluid-Mosaic Model is the best representation of the membrane.
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a. Protein and phospholipid components of membranes differ in different tissues (extremes are mitochondria and myelin sheath Percentage by Weight Membrane Protein Lipid Human myelin sheath 18 49 Human erythrocyte 49 43 Mitochondria (outer membrane) 52 48 Mitochondria (inner membrane) 76 24 Bacteria (gram positive) 75 25
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b. Membranes have characteristic lipid compositions Percentages Lipid Human Erythrocyte Myelin Mitochondria E. coli plasma plasma membrane Liver ( inner) membrane Phosphatidyl 19 10 45 0 choline Phosphatidyl 18 20 24 65 ethanolamine Phosphatidylglycerol 0 0 2 18 Phosphatidylinositol 1 1 6 0 Phosphatidylserine 8 8 1 0 Sphinogmyelin 17.5 8.5 3 0 Glycolipids 10 26 0 0 Cholesterol 25 26 3 0 Cardiolipin 0 0 18 17
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c. Phospholipids are asymmetrically oriented in the membranes (PC and sphingomyelin outside and PE, PS, PI inside). PC PE PS SP 50% 100% 100% 50% Outer Leaflet Inner Leaflet Human Erythrocyte Plasma Membrane PI p 373 Lehn
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d. Lateral diffusion of lipids and proteins is fast, whereas flip-flop across the membrane is slow.
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This note was uploaded on 03/15/2010 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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BCH4024 - Allen Lecture 30 - 33 - BCH 4024 (2010)...

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