BCH4024 - Allen Lecture 34

BCH4024 - Allen Lecture 34 - glycerol phosphate is a common...

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Glycerol Triacyl glycerols Fatty acids Steroids + Phospholipids Cholesterol Glycerol – P Acyl CoA Acetyl CoA Triose – P Pyruvate Ketone Glucose TCA Bodies cycle ATP 2 CO 2 Phospholipid Biosynthesis
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Functions of Phospholipids Membrane constituents Precursors of triglycerides (energy storage) Storage of polyunsaturated fatty acids (precursors of secondary messengers) Prostaglandin precursors) Lung surfactants
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Phospholipid and Triglyceride Biosynthesis phosphatidyl choline triglyceride (TG) a. The glycerol unit in both triglyceride (TG) and phospholipid (PL) biosynthesis is derived from the glycolytic pathway or salvage of glycerol. b. The fatty acids are derived from the fatty acid biosynthetic pathway.
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Glycerol in the form of
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Unformatted text preview: glycerol phosphate is a common precursor of both TG and PL biosynthesis. Enzyme present in most tissues Enzyme present only in liver and kidney Favors saturated fatty acids. Favors unsaturated fatty acids. Common precursor to TG and PL p 805 Lehn TG Biosynthesis General Pathways for Phospholipid Biosynthesis c. The head group is transferred by two mechanisms depending on the phospholipid to be made. d. Mammals use strategy II to make phosphatidyl choline In this case diacylglycerol and CDPcholine are key intermediates p 812 Lehn e. Eukaryotes use strategy I to make phosphatidyl inositol. In this case phosphatidic acid and inositol are key intermediates. p 811 Lehn Phosphatidic acid Summary...
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This note was uploaded on 03/15/2010 for the course BCH 4024 taught by Professor Allison during the Spring '08 term at University of Florida.

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BCH4024 - Allen Lecture 34 - glycerol phosphate is a common...

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