Cholesterol Biosynthesisa b c c d e 3C2 C6 C6 C5 C10 C15 C30 cholesterola. HMGCoA synthase is common to sterol and ketone body synthesisb. HMGCoA reductase makes mevalonate (MVA), the key and first intermediate of sterol biosynthesis. This is a highly regulated step.c. An “active isoprene” is made which may combine with another C5 unit to make C10 and C15 products.d. Two C15 units dimerize to form squalene, a C30 molecule.e. Squalene is cyclized using O2 and many enzymes to give cholesterol. f. The whole process is very energy dependent in terms of ATP and NADPH utilization. p 816-819 Lehn
has intentionally blurred sections.
Sign up to view the full version.
p 818 LehnsqualeneC5 C10 C15 C30 cholesterolp 818-819 Lehn
Bile Acid and Steroid BiosynthesisCholesterol is oxidized by mixed function oxidases (hydroxylases) to givea. Bile acids (salts) which are biological detergentsb. Steroid hormones such as - progesterone ( steroid precursor of