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DQ7 - Discussion question set 7 Chapter 16 The Cytoskeleton...

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Discussion question set 7 Chapter 16: The Cytoskeleton Microtubule (MT) and their motors 1) What are the differences between α -tubulin and β -tubulin subunits? - α’s GTP: does not perform GTP hydrolysis, not exchangeable-yet useful for protofilament stability - α: considered the – end due to inefficient elongation - β’s GTP: does perform GTP hydrolysis; is exchangeable - β: considered the + end due to relatively rapid elongation 2a) What is the advantage for protofilaments to form a cylinder like structure? - The cylindrical shape allows the 13 protofilaments to be ‘unaligned’ and capable interacting longitudinally and laterally -thus making the alpha helical structure b) What defines a microtubule “seam” and what protein stabilizes the seam? - The seam is stabilized by its imperfect side to side interactions of the alpha and betas; - The seam is defined as the sealing area? 3a) Define “Dynamic Instablitiy.” - Growth and shrinkage; inter-conversion between a growing and shrinking state, at
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