Ch07

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Unformatted text preview: Chapter 7: Protein Function Part I: Myoglobin and Hemoglobin Matching A) positively cooperative B) cyanosis C) His E7 D) decrease E) R F) hydrogen bonds G) increase H) symmetry I) His F8 J) ion pairs K) T L) hemolytic anemia 1. In the ______ form of hemoglobin, the iron ion is out of the plane of the porphyrin ring. Ans: K Level of Difficulty: Easy Section: 7.1.B Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 2. The conversion of hemoglobin from the T to the R form involves breaking C-terminal ______. Ans: J Level of Difficulty: Easy Section: 7.1.B Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 3. An increase in p CO 2 causes hemoglobin's affinity for oxygen to ______. Ans: D Level of Difficulty: Easy Section: 7.1.D Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 4. Hemoglobin's subunits bind oxygen in a ______ manner. Ans: A Level of Difficulty: Easy Section: 7.1.C Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 5. The absence of 2,3-BPG causes hemoglobin's affinity for oxygen to______. Ans: G Level of Difficulty: Easy Section: 7.1.D Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 6. The ______ model of allosterism requires subunits to change conformation simultaneously. Ans: H Level of Difficulty: Easy Section: 7.1.D Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 7. Sickle cell hemoglobin does not form fibers in the ______ form. Ans: E Level of Difficulty: Easy Section: 7.1.E Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 8. When unstable hemoglobins are degraded, the products often cause cell lysis, leading to a condition called ______. Ans: L Level of Difficulty: Easy Section: 7.1.E Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 9. When oxygen binds to heme, the oxygen forms a hydrogen bond with ______. Ans: C Level of Difficulty: Easy Section: 7.1.A Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 10. Mutations that favor the oxidation of the heme iron to the +3 oxidation state can cause ______. Ans: B Level of Difficulty: Moderate Section: 7.1.E Learning objective: Oxygen Binding to Myoglobin and Hemoglobin Multiple Choice 11. Which of the following is not a ligand to the porphyrin ring Fe 2+ ion in oxymyoglobin? A) His E7 B) His F8 C) Nitrogen atoms in the porphyrin ring D) Oxygen E) all are ligands Ans: A Level of Difficulty: Easy Section: 7.1.B Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 12. Which gas does not bind to the porphyrin ring Fe 2+ ion in myoglobin? A) NO B) CO C) CO 2 D) O 2 E) H 2 S Ans: C Level of Difficulty: Easy Section: 7.1.B Learning objective: Oxygen Binding to Myoglobin and Hemoglobin 13. Which of the following statements does not apply to the K value in the equation for the oxygen binding curve of myoglobin?...
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