ch11 - Chapter 11: Enzyme Catalysis Matching A) B) C) D) E)...

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Chapter 11: Enzyme Catalysis Matching A) high B) deprotonated C) protonated D) least resistance E) motion F) rate-determining G) leaving group H) short peptides I) amino acid J) low K) coenzymes L) concerted acid-base M) orient N) oxidoreductase 1. For efficient nucleophilic catalysis, a group such as the sulfhydryl on a cysteine residue must be able to form a good ______, in addition to being a good nucleophile. Ans: G Level of Difficulty: Easy Section: 11.3.B Learning objective: Catalytic Mechanisms 2. If an enzyme-catalyzed reaction has a low rate at low pH and high rate at higher pH, this implies that a group on either the enzyme or the substrate must be ______ for an efficient reaction. Ans: B Level of Difficulty: Easy Section: 11.3.A Learning objective: Catalytic Mechanisms 3. On a transition state diagram for a multistep reaction, the step with the greatest G is the ______ step. Ans: F
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Level of Difficulty: Easy Section: 11.2 Learning objective: Activation Energy and the Reaction Coordinate 4. On a transition state diagram for a one-step, very spontaneous reaction (large negative G ), a large peak (high G °) would imply a ______ rate for the reaction. Ans: J Level of Difficulty: Easy Section: 11.2 Learning objective: Activation Energy and the Reaction Coordinate 5. Metal ion cofactors can ______ the substrate at the active site, providing catalytic enhancement. Ans: M Level of Difficulty: Easy Section: 11.3.C Learning objective: Catalytic Mechanisms 6. Large rate enhancement in enzyme catalysis may occur when the binding of substrate reduces the ______ of the reacting groups. Ans: E Level of Difficulty: Easy Section: 11.2 Learning objective: Activation Energy and the Reaction Coordinate 7. Metal ion cofactors with more than one oxidation state may assist in catalysis by the ______ class of enzymes. Ans: N Level of Difficulty: Easy Section: 11.3.C Learning objective: Catalytic Mechanisms 8. Since proteins are limited in their abilities to catalyze oxidation-reduction reactions, enzymes often employ ______ to assist with catalysis. Ans: K Level of Difficulty: Easy
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Section: 11.1.C Learning objective: General Properties of Enzymes 9. Some serine proteases are believed to have developed by convergent evolution, because the ______ sequences of some serine proteases show no resemblance to those of others. Ans: I Level of Difficulty: Easy Section: 11.5.B Learning objective: Serine Proteases 10. Clustering several amino acid residues with favorable p K values at an active site can promote a(n) _________ catalytic mechanism. Ans: L Level of Difficulty: Easy Section: 11.3.A Learning objective: Catalytic Mechanisms Multiple Choice 11. An uncatalyzed reaction has a rate of 4.2 x 10 –7 sec –1 . When an enzyme is added the rate is 3.2 x 10 4 sec –1 . Calculate the rate enhancement caused by the enzyme. A)
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ch11 - Chapter 11: Enzyme Catalysis Matching A) B) C) D) E)...

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