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Unformatted text preview: Lecture 14 Atherosclerosis: Transporting Fat- from liver to get into the tissue- slow deteriorating problem (LDL level)- LDL should go back to liver but injured arteries generate apo-b receptors → attracts LDL- sets forth set of conditions → lead to build up of LDL particles and white particles, lumen gets smaller and smaller, LDL blocks up arteries and tissue can't breathe – foam cells; other cells stick to it: white streaks, - foam cells harden b/c of calcium which is also responding to injury - plaque - artery that is hardens : can't dilate- another set of conditions occur:- as plaque accumulates, pushes normal muscle cells in the blood vessel cells - when those cells that are at the very edge of the blood vessels are pushed out – sends signal for red blood cells- any time system is injured: stop blood flow- pushing against muscle cells in wall of artery: signal for red blood cells to come in - instigate series of reaction that makes red blood cells stick to wall of artery- then other RBC start to stick to that RBC and then accumulation of RBCs occurs at site of...
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This note was uploaded on 03/16/2010 for the course NS 1150 at Cornell.