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nslecture19 notes 2

nslecture19 notes 2 - Lecture 19 Part I VIII Evidence...

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Lecture 19 Part I VIII. Evidence against Leptin - obese humans: more leptin than non-obese humans - humans reverse of what was found in rats? - Set back because set point theory depends on finding mechanism to signal brain so disproved their finding - leptin concentrations – proportional to body fat - huge amount of variability in humans : doubts to whether one pill can be developed to suit everyone - women – higher % body fat then men: also higher leptin levels than men (opposite of leptin theory - leptin concentrations – increase during pregnancy but intake doesn't decrease - re-feeding after a period of fasting: caused almost immediate return of leptin levels: well before recovery of body fat - abdominal fat mRNA – doesn't change after 6-day fast, despite its sensitivity to lypolysis and a 40% reduction in serum leptin - Peritoneal (abdominal fat) – very plastic: but seems relatively insensitive to variations in body weight and starvations -
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