SolutionSet7

SolutionSet7 - Bioc100B Winter 2010 Rubin Solution Set #7...

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Bioc100B Winter 2010 Rubin Solution Set #7 This problem set is not required 1) Ligands that bind to and affect function of G-protein coupled receptors are often described as agonists, inverse agonists, or antagonists. Define each of these terms and find examples of physiological ligands or drug compounds that fit each category. What are the receptors that your examples bind and what are the functions of those receptors? If known, describe how each ligand interacts with its receptor. Examples are abundant. Here is one of each: An agonist is a molecule that binds to a receptor and increases its signaling response, i.e. it upregulates the signaling pathway. An example of an agonist is the opiate morphine, which binds to the μ - opioid receptor in the brain and gastrointestinal tract. The opioid receptor response in the brain results in analgesia (feeling “without pain”). While exact details of binding are unknown, it has been proposed that there are two ligand-binding sites on the receptor and that opioid receptors can form multimers. An inverse agonist binds to the same GPCR as an agonist but produces the opposite
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SolutionSet7 - Bioc100B Winter 2010 Rubin Solution Set #7...

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