100cps3s09 - Biochemistry & Molecular Biology 100C...

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Biochemistry & Molecular Biology 100C Problem Set #3 due: May 1, 2009 1. In mammalian liver, the dynamic steady-state condition cannot be maintained with priority- two fuel as sole oxidizable substrate for energy transduction. (a) Why not? Explain your answer. (b) What are the dietary and nutritional consequences of this limitation? 2. Hydroxymethyl glutaryl-CoA (HMG-CoA), a substrate for cholesterol biosynthesis, is produced by mammalian liver during steady-state ketosis. (a) In human patients, what is the clinical definition of ketosis? Of ketone bodies? (b) Diagram the synthesis of HMG-CoA from acetyl-CoA. (c) When liver is synthesizing ketone bodies at high rates, must it also then synthesize cholesterol at high rates? Why? (d) If you were hired by a big pharmaceutical company to develop a drug which blocked de novo liver cholesterol biosynthesis, what would be your conceptual strategy and which enzyme activity would you target? Why? (e) What side effects might you predict from such a drug? 3. Humans are susceptible to ethanol intoxication. (a) Outline the metabolic and physiological
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100cps3s09 - Biochemistry & Molecular Biology 100C...

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