Cohort Study 1.ppt - Cohort study Yan He Patient profile A pediatrician was called to the hospital to attend the dilivery of a newborn The mother a

Cohort Study 1.ppt - Cohort study Yan He Patient profile A...

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Cohort study Yan He
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Patient profile A pediatrician was called to the hospital to attend the dilivery of a newborn. The mother, a 28-year-old primigravida, had experienced elevated blood pressure during pregnancy. At the time of delivery, the male newborn was limp and cyanotic… Apgar Score at 1 , 5 and 10 minutes of life were 1, 2 and 3.
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Sign 0 1 2 Heart rate absent <100 >100 Respiration absent slow, irregular regular crying Muscle tone limp slow, flexion active motor Color blue,pale body pink, extremities blue completely pink Reflex response none Grimace cough,sneeze Tab.1. Apgar score for evaluation of neonatal asphyxia Apgar score is an index of neonatal asphyxia , which can ranging from 0 (very asphyxiated) to 10(no asphyxia)
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The parents of the newborn have questions about what the future will bring The pediatrician may find a variety of case report concerning infants who have had severe perinatal asphyxia, and have developed various acute and chronic medical problem. ( Chronic neurological disability, physical disability) however, there are also reports of instances of severe asphyxia during delivery in which the child later had normal neurological development and excellent school performance. How will you answer these questions?
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Cohort study schematic diagram of a cohort study of the relationship between perinatal asphyxia and chronic neurological disability Newborn infants Very low apgar High apgar disabled Not disabled Not disabled disabled Onset of study Direction of inquiry A large cohort study was conducted in the US on the utility of Apgar scores as predictors of chronic neurological disability. 49000 7 years
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What is a cohort? One of 10 divisions of a Roman legion Group of individuals sharing same experience followed up for specified period of time Examples cohort of guests at barbecue birth cohort occupational cohort of chemical plant workers
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Cohort Study Presence or absence of risk factor is determined before outcome occurs. Key Point:
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Definition of cohort studies An observational study in which subjects are sampled based on the presence(exposed) or absence (unexposed) of a risk factor of interest. These subjects are followed over time for development of a disease outcome of interest.
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