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2006 - UNIVERSITY OF HONG KONG BACHELOR OF SCIENCE FINAL...

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Unformatted text preview: UNIVERSITY OF HONG KONG BACHELOR OF SCIENCE: FINAL EXAMINATION BOTANY/ZOOLOGY: BIOL1106 Genetics Date: 25 May, 2006 Time: 9:30am—11:30am Candidates may use any self—contained, silent, battery-operated and pocket-sized calculator. The calculator should have numeral-display facilities only and should be used only for the purpose of calculation. It is the candidate's responsibility to ensure that his/her calculator operates satisfactorily. Candidates must record the name and type of their calculators on the front page of their examination scripts. Answer any FIVE questions. All questions carry equal marks. 1. A heterozygous genetic condition called “prune” in rats produces shortened and deformed tail. Matings between prunes produced 775 prunes : 388 normal progeny. (a) Is the hypothesis of a 3 2 1 ratio acceptable? (b) Does a 2 : 1 ratio fit the data better? (c) What phenotype is probably produced by the gene for prune when in homozygous condition? Show your working. 2. Discuss the significance of changes in chromosome number in organisms. 3. Write briefly (about half to one page each) on each of the following terms: (a) Genomes; (b) Glucose—6—phosphate dehydrogenase deficiency; (c) Hypothyroidism. 4. What is a gene? Discuss the various properties of a gene. 5. Discuss the possible sources of genetic variation. Petal color in a plant population is determined by a single gene with two codominant alleles, R and W. RR plants have red flowers, WW plants have white flowers, and RWplants have flowers with red and white striped petals. In a random sample of plants from this population, you find 140 plants with red flowers, 760 with striped flowers, and 100 with white flowers. (a) (b) (C) ((1) Calculate the frequency of each genotype and the frequency of each allele. What is the observed heterozygosity at the locus? Is this plant population in Hardy-Weinberg equilibrium? Why or why not? If the conditions for the Hardy—Weinberg equilibrium are met, what happens to allele frequencies in the population over time? What happens to genotype frequencies over time? The A, B, AB, and 0 blood types are determined by a single locus with three alleles, 1A, 13, and 10. [A and 13 are codominant while BOTH being dominant to 10. At an unlinked molecular marker locus, there are four codominant alleles, M1, M2, M3, and M4. Given that a child has blood type A with a genotype of M1M4 at the marker locus: (81) (b) (C) What are the possible blood types and marker genotypes of the mother? Which blood type(s) or marker genotypes would exclude a male from being the father? Briefly discuss the applications of forensic DNA methods in determining parentage and in detecting illegal hunting and collecting of endangered species. The probabilities of exceeding different chi-square values for degree: of freedom from 1 10 50 when the expected hypothesis is true‘ ummquauwxmfi; -\~.~.~. MkLuNr-‘Q 20 25 30 50 Probabilities .95 .90 .70 .50 .30 .20 ' .10 .05 _ .01 .001 .004 .016 ' .15 .46 1.07 1.64 2.71 3.84 6.64 10.83 .10 .21 .71 1.39 2.41 3.22 4.61 5.99 9.21 13.82 .35 .53 1.42 2.37 3.67 4.64 6.25 7.82 11.35 16.27 .71 1.06 2.20 3.36 4.88 5.99 7.78 9.49 13.28 18.47 1.15‘ 1.61 3.00 4.35 6.06 7.29 9.24 11.07 15.09 20.52 1.64 2.20 3.83 5.35 7.23 8.56 10.65 12.59 16.81 22.46 2.17 2.83 4.67 6.35 8.38 9.80 12.02 14.07 18.48 24.32 2.73 3.49 5.53 7.34 9.52 11.03 13.36 15.51 20.09 26.13 3.33 4.17 6.39 , 8.34 10.66 12.24 14.68 16.92 21.67 27.88 3.94 4.87 7.27 9.34 11.78 13.44 15.99 18.31 23.21 29.59 4.58 5.58 8.15 10.34 12.90 14.63 17.28 19.68 24.73 31.26 5.23 6.30 9.03 11.34 14.01 15.81 18.55 21.03 26.22 32.91 5.89 7.04 9.93 12.34 15.12 16.99 19.81 22.36 27.69 34.53 6.57 7.79 10.112 13.34 16.22 18.15 21.06 23.69 29.14 36.12 7.26 8.55 11.72 14.34 17.32 19.31 22.31 25.00 30.58 37.70 10.85 12.44 16.27 19.34 22.78 25.04 23.41 31.41 37.57 45.32 14.61 16.47 20.87 24.34 28.17 30.68 34.38 37.65 44.31 52.62 18.49 20.60 25.51 29.34 33.53 36.25 40.26 43.77 50.89 59.70 34.76 37.69 44.31 49.34 54.72 58.16 63.17 67.51 76.15 116.66 I <~————1—————> du nutreject l reject at .05 level W... “Abridged from Table IV of Fisher and Ya“ St I' (' IT at ‘ ' 1 - , . _ ~ of the uuthun and publighgrsl I, a 1: sea a u for Biological, Agnwllurul and Madncal Ragga-h, Ollvor and Boyd Ltd., Edmbuygh, hy pen-mum" ——- END OF PAPER --- ...
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