BIOL2609_L2_2007

BIOL2609_L2_2007 - M o l e c u l a r E c o l o g y L e c t...

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Unformatted text preview: M o l e c u l a r E c o l o g y L e c t u r e 2 W h y i s D N A t h e g e n e t i c m a t e r i a l ? • L i f e i s i n c r e d i b l y d i v e r s e b u t ( a l m o s t ) a l l l i f e s h a r e s o n e c o m m o n f e a t u r e – T h e g e n e t i c c o d e i s D N A • D e o x y r i b o n u c l e i c a c i d • T h i s m a k e s m o l e c u l a r e c o l o g y a v e r y b r o a d l y a p p l i c a b l e s c i e n t i f i c d i s c i p l i n e • B u t w h y d o e s a l l l i f e s h a r e t h i s c o m m o n a l i t y ? C r y s t a l l i n e D N A W h y D N A ? • T o a n s w e r t h i s q u e s t i o n , w e f i r s t n e e d t o s t e p b a c k i n t i m e a n d c o n s i d e r t h e e v o l u t i o n o f l i f e o n E a r t h … … … … … . . T h e s t r u c t u r e o f D N A • J a m e s W a t s o n & F r a n c i s C r i c k ( 1 9 5 9 ) C a m b r i d g e , U K • E l u c i d a t e d s t r u c t u r e o f D N A • A l s o b a s e d u p o n X R D w o r k o f R o s a l i n d F r a n k l i n a t K C L , U K N u c l e i c a c i d s • A n u c l e i c a c i d c o n s i s t s o f : A n i t r o g e n o u s b a s e A p e n t o s e s u g a r A p h o s p h a t e g r o u p • T h e r e a r e 2 t y p e s o f n u c l e i c a c i d : D N A R N A N i t r o g e n o u s b a s e s • E a c h n u c l e i c a c i d c o n t a i n s 4 k i n d s o f b a s e – T h e p u r i n e b a s e s a d e n i n e ( A ) a n d g u a n i n e ( G ) a r e f o u n d i n D N A a n d R N A – T h e p y r i m i d i n e b a s e s i n D N A a r e c y t o s i n e ( C ) a n d t h y m i n e ( T ) – I n R N A u r a c i l ( U ) i s f o u n d i n s t e a d o f T , t h e y h a v e s l i g h t l y d i f f e r e n t m e t h y l s u b s t i t u t i o n s • A b a s e l i n k e d t o a s u g a r i s c a l l e d a n u c...
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This note was uploaded on 03/19/2010 for the course DEB BIOL2609 taught by Professor Drstephenb.pointing during the Spring '10 term at HKU.

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BIOL2609_L2_2007 - M o l e c u l a r E c o l o g y L e c t...

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