The heat shock response•The heat shock response is a ubiquitous,protective (and homeostatic) cellular response tocope with heat-induced damage to proteins•Many ‘heat shock proteins’ (HSP’s) are producedas a response–These can be molecular chaperones, or ATP-dependantproteases•They function in protein folding, repair anddegradation (under both normal and stressconditions)
Heat shockCo-factors activatede.g. stabilization of usuallyunstable molecules, melting ofmRNA structuresBinding to promoter sequencesof sigma factor (prokaryotes) orheat shock response elements(eukaryotes)Heat shock protein genetranscriptionTranslation of heat shockproteins which act toprotect cellular proteinsfrom heat damageFeedback control
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