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BIOL2609_L22_2007

BIOL2609_L22_2007 - Molecular Ecology ECOL 2007 Lecture 22...

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Molecular Ecology ECOL 2007 Lecture 22: Stress responses: Expression of stress protein genes
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The heat shock response The heat shock response is a ubiquitous, protective (and homeostatic) cellular response to cope with heat-induced damage to proteins Many ‘heat shock proteins’ (HSP’s) are produced as a response These can be molecular chaperones, or ATP-dependant proteases They function in protein folding, repair and degradation (under both normal and stress conditions)
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Heat shock Co-factors activated e.g. stabilization of usually unstable molecules, melting of mRNA structures Binding to promoter sequences of sigma factor (prokaryotes) or heat shock response elements (eukaryotes) Heat shock protein gene transcription Translation of heat shock proteins which act to protect cellular proteins from heat damage Feedback control
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