Neck Circumstance.pdf - ORIGINAL RESEARCH published 29 November 2017 doi 10.3389\/fphys.2017.00965 Neck Circumference a Novel Indicator for Hyperuricemia

Neck Circumstance.pdf - ORIGINAL RESEARCH published 29...

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ORIGINAL RESEARCH published: 29 November 2017 doi: 10.3389/fphys.2017.00965 Frontiers in Physiology | 1 November 2017 | Volume 8 | Article 965 Editedby: Elisabeth Lambert, Swinburne University of Technology, Australia Reviewedby: Ayo Priscille Doumatey, National Institutes of Health (NIH), United States Marli Maria Knorst, Federal University of Rio Grande do Sul (UFRGS), Brazil *Correspondence: Jingtao Dou [email protected] Yan He [email protected] These authors have contributed equally to this work. Specialtysection: This article was submitted to Integrative Physiology, a section of the journal Frontiers in Physiology Received: 06 September 2017 Accepted: 13 November 2017 Published: 29 November 2017 Citation: Jiang J, Cui J, Yang X, Wang A, Mu Y, Dong L, Wang S, Gaisano H, Dou J and He Y (2017) Neck Circumference, a Novel Indicator for Hyperuricemia. Front. Physiol. 8:965. doi: 10.3389/fphys.2017.00965 Neck Circumference, a Novel Indicator for Hyperuricemia JiajiaJiang 1† ,JiaCui 2† ,XinghuaYang 1 ,AnpingWang 2 ,YimingMu 2 ,LiguangDong 3 , ShuyuWang 4 ,HerbertGaisano 5 ,JingtaoDou 2 * andYanHe 1,6 * 1 Department of Epidemiology and Biostatistics, School of Public Health, Capital Medical University, Beijing, China, 2 Department of Endocrinology, Chinese PLA General Hospital, Beijing, China, 3 Department of Endocrinology, Peking University Shougang Hospital, Beijing, China, 4 Beijing Institute of Hypertension, Beijing, China, 5 Departments of Medicine and Physiology, University of Toronto, Toronto, ON, Canada, 6 Municipal Key Laboratory of Clinical Epidemiology, Beijing, China Background: Waist circumference has been correlated with the risk of hyperuricemia. Whether neck circumference is also associated with hyperuricemia has not been assessed. This study aimed to investigate whether neck circumference is associated with hyperuricemia. Methods: This study population from Beijing is part of the larger China-wide Risk Evaluation of Cancers in Chinese Diabetic Individuals: a lONgitudinal (REACTION) study. For this Beijing sub-center cross-sectional study, a total of 8971 subjects were recruited. Gender-specific multivariable-adjusted regression analyses were conducted to analyze the association of neck circumference and waist circumference with hyperuricemia and the association of neck circumference with serum uric acid levels in the non- hyperuricemia population. Results: After adjusting for confounding variables, regression analyses showed that neck circumference was positively associated with hyperuricemia [OR, 2.61 (1.86–3.67) for males and 3.27 (2.53–4.22) for females] in both genders; further, neck circumference was also positively associated with serum uric acid levels in non-hyperuricemia subjects [b, 2.58 (1.76–3.39) for males and 4.27 (3.70–4.84) for females] in both genders. Additionally, we demonstrated that neck circumference was similar to waist circumference in terms of the strength of association (OR, 3.03 for waist circumference vs. 2.61 for neck circumference in males, and 3.50 vs. 3.27 for females) with hyperuricemia and the ability to predict hyperuricemia (AUC, 0.63 for waist circumference vs. 0.61 for neck circumference in males, and 0.66 vs. 0.66 in females).
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