chapter13_review_and_practice_problems - Review and...

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Review and Practice Problems for Chapter 13 Chapter 13: Vesicular Traffic Concept Review Questions 1. Vesicle budding is associated with coat proteins. What is the role of coat proteins in  vesicle budding? How are coat proteins recruited to membranes? What kinds of  molecules are likely to be included and excluded from newly formed vesicles? 2. I-cell disease is an example of an inherited human defect in protein targeting that affects  an entire class of proteins, i.e. soluble enzymes of the lysosome. Based on what you  know about lysosome enzyme targeting, propose a molecular defect in I-cell disease  that explains this event. Why does it affect the targeting of an entire class of proteins?  What other types of mutations might produce the same phenotype? 3. The TGN is the site of multiple sorting events as proteins and lipids exit the Golgi  complex. Compare and contrast the sorting of proteins to lysosomes versus the  packaging of proteins into regulated and constitutive secretory vesicles.  4. Describe how pH plays a role in cargo/receptor binding and unbinding at donor and  recipient locations, respectively.  5. Clathrin adaptor protein (AP) complexes bind directly to the cytoplasmic face of  membrane proteins and can also interact with clathrin. Discuss the four adaptor proteins  discussed in lecture and explain what role they play in membrane trafficking.  6. Discuss the mechanism and cellular important of receptor-mediated endocytosis.  7. Sorting signals that cause retrograde transport of a protein are sometimes called  retrieval sequences. List two examples of retrieval sequences for soluble and membrane  proteins of the ER. How does the presence of a retrieval sequence on a soluble ER 
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protein result in its retrieval from the cis-Golgi? Describe how the concept of a retrieval 
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This note was uploaded on 03/20/2010 for the course BIS BIS 104 taught by Professor Privalsky during the Spring '09 term at UC Davis.

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chapter13_review_and_practice_problems - Review and...

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