13 Carbohdrates - TCA-1

13 Carbohdrates - TCA-1 - Carbohydrates: Tricarboxylic Acid...

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Carbohydrates: Tricarboxylic Acid (TCA) Cycle Citric Acid Cycle (CAC) Krebs Cycle HNFE 3025 Fall 2009
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Overview of Metabolism in a Muscle Cell 2 Blood glucose Blood FFA Blood lactate 1 Glycogenolysis 2 Glycogenesis 3 Glycolysis 4 TCA Cycle 5 Electron transport chain 6 Beta oxidation
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Mitochondrion 3 Mitochondrial DNA is: maternally derived circular codes for 37 genes -13 polypeptides -22 tRNA molecules - 2 rRNA molecules Not shown are porins; outer membrane channel proteins allowing ions and molecules up to 5 kDa through.
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Computer Generated Picture 4 Densely packed cristae (yellow). Inner membrane is light blue and outer membrane darker blue.
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Mitochondria The spherical shape is more likely to be found in tissues other than skeletal muscle In skeletal muscle, mitochondria are thought to be arranged in more of a reticulum Spans from plasma membrane to the inner muscle cell Subsarcolemmal mitochondria Found just under plasma membrane (sarcolemma in muscle) • Provides needed ATP for the membrane transport processed Intermyofibrillar mitochondria • Located in areas where cross-bridge cycling (interaction between actin and myosin) occurs Provides needed ATP for muscle contraction 5
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6 Copyright ©2007 American Physiological Society Tarnopolsky, M. A. et al. Am J Physiol Regul Integr Comp Physiol 292: R1271-R1278 2007; doi:10.1152/ajpregu.00472.2006 Fig. 1. Transmission electron micrograph of human skeletal muscle Subsarcolemmal mitochondria Intermyofibrillar mitochondria Subsarcolemma Capillary
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Electron Microscope - Mitochondria 7 Subsarcolemmal mitochondria Intermyofibrillar mitochondria From Hulver-Frisard Laboratory
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Electron Microscope - Mitochondria 8 Muscle cell Nucleus Intermyofibrillar Mito Subsarcolemmal mito capillary From Hulver-Frisard Laboratory
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Oxidation of Pyruvate A major fate of pyruvate in cells containing mitochondria is oxidation to produce acetyl CoA, CO 2 and NADH Since pyruvate has the potential to be converted into glucose, but acetyl CoA cannot, pyruvate oxidation is very tightly controlled. ex. – times of CHO deprivation
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13 Carbohdrates - TCA-1 - Carbohydrates: Tricarboxylic Acid...

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