14 Carbohydrate - ETC and RER_RQ

14 Carbohydrate - ETC and RER_RQ - Electron Transport Chain...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
Electron Transport Chain Respiratory Exchange Ratio Respiratory Quotient HNFE 3025 Fall 2009 1
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 Big Picture Oxidative phosphorylation (OxPn) provides almost all the ATP our cells need (RBCs exception) Even if we train 4 hours a day, constantly using PCr and anaerobic glycolysis, OxPn is necessary to regenerate PCr and to oxidize the lactate we produce during the training sessions. OxPn takes place in mitochondria. The major fuels are CHO, Lipid and Protein (AAs). Each must be degraded to acetyl groups to enter TCA cycle.
Background image of page 2
3 Two Major Components Oxidation part: Fuels to acetyl CoA (some NADH generated) Oxidation of acetyl CoA in TCA cycle (more NADH generated + some FADH 2 ) 2 oxidized and O 2 is reduced Phosphorylation part Capture of the energy released during electron transfer to O 2 by phosphorylating ADP
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 β α α γ Succinate:CoQ Oxidoreductase (Complex II) b Cyt c Cyt bc1 Cyt bc1 COX COX NADH:CoQ Oxidoreductase (Complex I) Mitochondrial electron transport and oxidative phosphorylation CoQ:Cytochrome c Oxidoreductase (Complex III) Cytochrome c Oxidase (Complex IV) + NAD Succinate Fumarate H H H ADP + Pi ATP H Q a 2 e - Q Q Q Q CoQ β β α ε δ OSCP d F6 Mitochondrial Matrix Succinate DH (FAD) Proton pumping integral to entire concept of oxidative phoshporylation
Background image of page 4
Chemiosmotic Theory 5 The connection between electron transfer from reduced coenzymes to oxygen (using the electron transport chain) and the formation of ATP is proton pumping from the matrix of the mitochondrion across the inner membrane to the intermembrane space (cytosol). This creates an electrochemical gradient that can be used to drive the phosphorylation of ADP to make ATP. This is known as the chemiosmotic theory . Peter Dennis Mitchell (September 29, 1920–April 10, 1992) was a British biochemist who was awarded the 1978 Nobel Prize for Chemistry for his discovery of the chemiosmotic mechanism of ATP synthesis.
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 Transmembrane Electrochemical Potential The transmembrane electrochemical potential (proton motive force) abbreviated ∆μ H + ( ∆ρ or pmf) consists of a transmembrane electric potential given the short form ∆ψ and a pH difference shown as pH. Therefore, ∆μ H + consists of ∆ψ and pH. Proton pumping generates a proton-motive force based on an electrical potential difference and a pH difference across the inner mitochondrial membrane
Background image of page 6
7 A Simplified View of the Proton Electrochemical Gradient
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Water level above dam Dam Water level below dam Potential energy of water Think of how some of our electricity is made by using the energy of falling water to turn the blades of turbines in a magnetic field, thus generating an electric current. Analogy to electrical potential
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/23/2010 for the course HNFE 3025 taught by Professor Mwhulver during the Spring '10 term at Virginia Tech.

Page1 / 37

14 Carbohydrate - ETC and RER_RQ - Electron Transport Chain...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online